@font-face {
    font-family: monsterrat;
    src: url('/font?font=monsterrat');
}

html, body {
    height: 100%;
    margin: 0;
    overflow-y: scroll;
}

/* Use Flexbox to lay out the body */
body {
    display: flex;
    flex-direction: column;
    min-height: 100vh;
    font-family: monsterrat;
}


/* VIEWING PROTEIN HERE */

.top-right-window {
    width: 250px;
    height: 250px;
    position: fixed;
    overflow: hidden;
}

#bottomAlphaFold {
    position: absolute;
    bottom: 0;
}

/* Style for the canvas element */
.protein-canvas {
    border: 3px solid #333;
    border-radius: 10px;
    box-shadow: 0 0 15px rgba(0, 0, 0, 0.5);
    background-color: #f5f5f5;
    max-width: 100%;
    max-height: 100%;
    display: block;
    margin: auto;
}

/* APPLYING MAIN CONTENT HERE */

/* Main content will take up all the available space between the navbar and footer */
.main-content {
    flex: 1;
    width: 1200px;
}

/* Footer Styles */
.footer {
    background-color: #f8f9fa;
    text-align: center;
    padding: 20px 0;
}

.container {
    width: 100%;
}

.suggestions-box {
    display: none;
    position: absolute;
    top: calc(100% + 5px);
    left: 0;
    width: 100%;
    background: white;
    border: 1px solid #ccc;
    border-radius: 4px;
    max-height: 150px;
    overflow-y: auto;
    z-index: 1000;
}
.suggestion-item {
    padding: 10px;
    cursor: pointer;
}
.suggestion-item:hover {
    background-color: #007bff;
    color: white;
}

.iframe-container {
    display: none;
    text-align: center;
    margin-top: 40px;
    width: 100%;
}

iframe {
    height: 600px;
    border: none;
    border-radius: 8px;
    box-shadow: 0 4px 10px rgba(0, 0, 0, 0.1);
}

#iFrameData {
    text-align: center;
    margin-bottom: 30px;
    font-size: 28px;
    color: #444;
    font-weight: bold;
}

.alert {
    width: 500px;
    max-width: 1050px;
    margin: 0 auto;
    border-radius: 8px;
    box-shadow: 0 2px 5px rgba(0, 0, 0, 0.1)
}

.custom-container {
    margin-top: 20px
}

/* Navbar styling */
.navbar {
    background-color: #f8f9fa;
    box-shadow: 0 2px 5px rgba(0, 0, 0, 0.1);
    padding: 10px 300px;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.navbar .logo {
    font-size: 24px;
    font-weight: bold;
    color: #333;
}

/* Navbar items container */
.navbar-items {
    display: flex;
    list-style: none;
    margin-top: 15px;
}

.navbar-items li {
    margin-left: 20px;
    margin: 0 auto;
}

.nav-link {
    text-decoration: none;
    color: #ffffff;
    font-weight: 600;
    text-transform: uppercase;
    padding: 5px 10px;
    display: inline-block;
    transition: color 0.3s ease;
    margin: 0 auto;
}

/* Hover and active link styles */
.nav-link:hover {
    color: #85c0ff;
}

.nav-link.active {
    font-weight: bold;
    color: #a8cfff;
}

.nav-link.search {
    font-weight: bold;
    color: #1a81ff;
}

.nav-link.propensity {
    font-weight: bold;
    color: #ff8b17;
}

/* Make navbar responsive */
.navbar-toggler {
    display: none;
}

/*
    This is exclusively for Nav. TABS
*/

.nav-tabs .nav-link.active {
    background-color: #ecf6ff; /* light blue, for example */
    color: #00796b;            /* darker teal text */
    border-color: #e0e8f0 #e0e8f0 #ecf6ff; /* match Bootstrap's border logic */
}

.tab-content > .tab-pane {
    background-color: #ecf6ff;
    border: 1px solid #e0e8f0;
    border-top: none;
    border-radius: 10px;
    border-top-left-radius: 0;
    border-top-right-radius: 0;
    padding: 20px;
    width: 1280px;
    margin: 0 auto;
    margin-top: -16px;
    margin-bottom: 20px;
}

/* Media queries for mobile responsiveness */
@media (max-width: 1079px) {
    .navbar-items {
        display: none;
        width: 100%;
        flex-direction: column;
        text-align: center;
        margin-top: 10px;
    }

    .navbar-items li {
        margin-left: 0;
        margin-bottom: 10px;
    }

    .navbar-toggler {
        display: block;
        background-color: #007bff;
        border: none;
        color: white;
        padding: 10px 15px;
        cursor: pointer;
    }

    .navbar-toggler.active + .navbar-items {
        display: flex;
    }
}

.btn-primary {
    transition: background-color 0.3s;
}

.btn-primary:hover {
    background-color: #004085;
}

.lds-dual-ring {
    color: #297fff;
    margin: auto; 
}
.lds-dual-ring,
.lds-dual-ring:after {
    box-sizing: border-box;
}
.lds-dual-ring {
    display: inline-block;
    width: 80px;
    height: 80px;
}
.lds-dual-ring:after {
    content: " ";
    display: block;
    width: 64px;
    height: 64px;
    margin: 8px;
    border-radius: 50%;
    border: 6.4px solid currentColor;
    border-color: currentColor transparent currentColor transparent;
    animation: lds-dual-ring 1.2s linear infinite;
}
@keyframes lds-dual-ring {
    0% {
        transform: rotate(0deg);
    }
    100% {
        transform: rotate(360deg);
    }
}

/*
    Entering some custom CSS of my own
*/

.landing-page-button {
    color: white;
    background-color: #529fec;
    border: 1px solid rgb(55, 113, 250);
    margin-left: 10px;
    transform: translateY(-5px);
    transition: background-color 0.2s ease, color 0.2s ease, border 0.2s ease;
}

.landing-page-button:hover {
    color: black;
    background-color: #d4e9ff;
    border: 1px solid rgb(114, 156, 255);
}

.index-options {
    color: #d3d3d3;
    background-color: #1870c8;
    padding: 2px;
    padding-left: 5px;
    padding-right: 5px;
    border-radius: 4px;
    cursor: pointer;
    margin-left: 5px;
    transition: background-color 0.1s ease, color 0.1s ease;
}

.index-options:hover{
    background-color: #3a92ea;
    color: #ffffff;
    text-decoration: none;
}

.bullet-point {
    font-weight: 700;
    color: #0051a8;
    text-decoration: none;
    transition: color 0.1s linear;
}

.bullet-point:hover {
    color: #186eca;
}

.header-bar {
    position: relative;
    font-size: 32px;
    color: #333;
    font-weight: bold;
    padding-left: 20px; /* Space for the bar */
    margin: 40px 0 20px;
    text-align: left;
}

.header-bar::before {
    content: "";
    position: absolute;
    left: 0;
    top: 0;
    height: 100%;
    width: 6px;
    background-color: #1d5cf0;
    border-radius: 2px;
    transition: background-color 0.3s ease;
}

.section-lead-major {
    position: relative;
    font-size: 26px !important;
    color: #2a2a2a;
    font-weight: 700;
    padding-left: 20px;
    margin: 40px 0 20px;
    text-align: justify;
    background-color: transparent;
    line-height: 1.6;
}

.section-lead-minor {
    position: relative;
    font-size: 20px !important;
    color: #2a2a2a;
    font-weight: 400;
    padding-left: 20px;
    margin: 40px 0 20px;
    text-align: justify;
    background-color: transparent;
    line-height: 1.6;
}

.header-bar:hover::before {
    background-color: #719cff;
}

/*
    Entering for the landing page image
*/

.background-wrapper {
    position: relative;
    background-color: rgba(105, 164, 253, 0.52); /* Background color */
    width: 100%;
    padding: 120px 0;
    text-align: center;
    overflow: hidden;
}

.background-wrapper-2 {
    position: relative;
    width: 60%;
    margin: 0 auto;
    padding-bottom: 140px;
    border-radius: 5px;
    text-align: center;
    overflow: hidden;
}

.background-image {
    position: absolute;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background: url('/picture?picture=icons/haemoglobin.png') center/contain no-repeat;
    opacity: 0.1; /* Image opacity */
    z-index: 1;
}
.content-layer {
    position: relative;
    z-index: 2;
}

.feature-stack {
    display: flex;
    flex-direction: column;
    gap: 20px;
    width: 100%;
    max-width: 1000px;
    margin: 0 auto;
}

.feature-bar-link {
    text-decoration: none;
    color: inherit;
    display: block;
}

.feature-bar {
    display: flex;
    align-items: center;
    background-color: #d8ecff;
    border-radius: 6px;
    padding: 20px;
    box-shadow: 0 2px 5px rgba(0, 0, 0, 0.05);
    transition: background-color 0.3s ease;
    width: 100%;
    text-decoration: none;
}

.feature-bar:hover {
    background-color: #bee0ff;
    text-decoration: none;
}

.feature-bar-icon {
    width: 50px;
    height: 50px;
    flex-shrink: 0;
    margin-right: 20px;
}

.feature-bar-text {
    font-family: 'Montserrat', sans-serif;
    font-size: 16px;
    color: #333;
    line-height: 1.5;
    text-align: center;
    width: 100%;
}

.feature-bar-text:hover {
    text-decoration: none;
}

/*
    Going to use this to display general protein information here
*/

/* Specific styles for the custom table container */
.protein-info-container {
    background-color: #e5e5e5;
    padding: 30px;
    border-radius: 10px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    max-width: 1280px;
    margin: 0 auto;
    overflow-x: auto;
    position: relative;
}

/* New window styling for the top-right corner */
.protein-info-container .top-right-window {
    position: absolute;
    top: 20px;
    right: 20px;
    background-color: #fff;
    padding: 15px;
    border-radius: 8px;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
    width: 300px;
    max-height: 300px;
    overflow-y: auto;
    z-index: 10;
}

/* Style for the disclaimer (customized to sit below 3DStructureInfo) */
.disclaimer-text {
    text-align: center;
    font-size: 16px;
    color: rgba(0, 0, 0, 0.7);
}

/* Table Styling - Scoped to the protein-info-container */
.protein-info-container .table {
    table-layout: fixed;
    width: 100%;
    border-collapse: collapse;
    background-color: #fff;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.1);
    border-radius: 10px;
}

/* Header Styling */
.protein-info-container .table th {
    background-color: #007bff;
    color: #fff;
    padding: 12px 16px;
    font-size: 16px;
    text-align: left;
    font-weight: bold;
    border-bottom: 2px solid #0066cc;
    text-transform: uppercase;
}

/* Table Cell Styling */
.protein-info-container .table th, .protein-info-container .table td {
    padding: 12px 16px;
    border: 1px solid #e0e0e0;
    font-size: 14px;
    color: #333;
    line-height: 1.6;
    /* transition: background-color 0.3s ease, transform 0.2s ease, box-shadow 0.3s ease; */
}

/* Default cell background (light blue-ish) */
.protein-info-container .table td {
    background-color: #e3f2fd;
    color: #333;
    word-wrap: break-word;
    overflow-wrap: break-word;
    white-space: normal;
    text-align: left;
    white-space: pre-wrap;
}

/* Key Column */
.protein-info-container .table td.key {
    width: 200px;
    text-align: center;
    color: #444;
    border-right: 2px solid #ddd;
    background-color: #f7f7f7;
    font-weight: 700;
}
/* 
.protein-info-container .table td.value:hover {
    background-color: #b0bec5;
    color: #333;
    transform: none;
} */

/* Focus State for Table Cells */
.protein-info-container .table td:focus, .protein-info-container .table th:focus {
    outline: 2px solid #007bff;
    background-color: #e1f4fd;
}

/* Alternating Row Backgrounds */
.protein-info-container .table tr:nth-child(even) {
    background-color: #f9f9f9;
}

.protein-info-container .table tr:nth-child(odd) {
    background-color: #ffffff;
}

/* Responsive Table - Stack cells vertically on smaller screens */
@media screen and (max-width: 1079px) {
    .protein-info-container .table th, .protein-info-container .table td {
        display: block;
        width: 100%;
        text-align: left;
        margin-bottom: 10px;
    }

    .protein-info-container .table td.key {
        background-color: #f7f7f7;
        font-weight: 700;
    }

    .protein-info-container .table td.value {
        margin-left: 20px; /* Add some left margin for better readability */
    }

    .top-right-window {
        visibility: hidden;
    }

    .top-right-window-disclaimer {
        visibility: hidden;
    }
}


/* PROTEIN SEQUENCE PTM STATISTICS HERE */
/* Main container styles for protein stats */
.protein-statistics-container {
    background-color: #e5e5e5;
    padding: 30px;
    border-radius: 10px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    max-width: 1280px;
    margin: 0 auto;
    overflow-x: auto;
    margin-bottom: 20px;
}

/*
    INCLUDING THIS HERE EXCLUSIVELY FOR STATISTICS TABLE
*/

#ptmTableSummary table {
    font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
    background-color: rgb(148, 148, 148);
    border-radius: 8px;
    overflow: hidden;
    margin-top: 20px;
    box-shadow: 0 0 12px rgba(0, 0, 0, 0.08);
    border: solid 1px black;
}

#ptmTableSummary th,
#ptmTableSummary td {
    border: 1px solid #4c4c4c;
    padding: 12px 16px;
    text-align: center;
    vertical-align: middle;
}

#ptmTableSummary thead th {
    background-color: #3f51b5;
    color: rgb(0, 0, 0);
    font-weight: 600;
    position: sticky;
    top: 0;
    z-index: 1;
}

#ptmTableSummary tbody tr:hover {
    background-color: #4c4c4c;
}

#ptmTableSummary td {
    background-color: rgb(186, 226, 254);
    transition: background-color 0.1s ease-in-out;
}

#ptmTableSummary td:hover {
    background-color: #4c4c4c;
    cursor: pointer;
}

/* Heading */
.protein-statistics-container h1 {
    text-align: center;
    margin-bottom: 30px;
    font-size: 28px;
    color: #444;
    font-weight: bold;
}

/* Flexbox for rows */
.row {
    display: flex;
    flex-wrap: wrap;
    justify-content: space-between;
    gap: 20px;
}

/* Column styles */
.col {
    flex: 1 1 calc(33% - 20px);
    min-width: 250px;
    box-sizing: border-box;
}

/* Stat box styles */
.stat-box {
    background-color: #fff;
    border-radius: 10px;
    box-shadow: 0 4px 10px rgba(0, 0, 0, 0.1);
    padding: 20px;
    text-align: center;
    /* transition: transform 0.3s ease, box-shadow 0.3s ease; */
}

/* Icons */
.stat-box i {
    margin-bottom: 10px;
    color: #007bff;
}

/* Links within the stat box */
.stat-box a {
    text-decoration: none;
    color: inherit;
}

/* Stat title */
.stat-box h3 {
    font-size: 2rem;
    margin: 10px 0;
    color: #555;
}

/* Stat description */
.stat-box p {
    font-size: 1rem;
    color: #777;
}

/* Colors for different stat boxes */
.info {
    background-color: #e3f2fd;
    border-left: 5px solid #1e88e5;
}

.success {
    background-color: #e8f5e9;
    border-left: 5px solid #43a047;
}

.warning {
    background-color: #fff3e0;
    border-left: 5px solid #ff9800;
}


/* Focus state */
.stat-box a:focus {
    outline: 2px solid #007bff;
}

/* Responsive design for smaller screens */
@media (max-width: 768px) {
    .col {
        flex: 1 1 100%;
    }
}



@font-face {
    font-family: 'perfectDOSVGA';
    src: url('../data/fonts/perfect_dos_vga.ttf') format('truetype'),
        url('../data/fonts/perfect_dos_vga.woff') format('woff'),
        url('../data/fonts/perfect_dos_vga.woff2') format('woff2');
}


/* DISPLAYING THE PROTEIN SEQUENCE HERE */

.protein-sequence-container {
    background-color: #e5e5e5;
    padding: 10px;
    border-radius: 10px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    max-width: 1280px;
    margin: 0 auto;
    overflow-x: auto;
}

/* Container for sequence blocks */
#sequenceDisplayer {
    display: inline-block;
    flex-wrap: wrap;
    gap: 20px;
    padding: 30px;
    margin-top: 10px;
    margin-bottom: 10px;
    background: #f3f3f3; 
    border-radius: 12px;
    box-shadow: 0px 4px 15px rgba(0, 0, 0, 0.1); 
    overflow: hidden;
    flex-grow: 1;
    /* width: 95%; */
    box-sizing: border-box;
    justify-items: left;
    justify-content: left;
    margin: 0 auto;
}

/* Each individual block of sequence */
.sequence-block {
    padding-top: 12px;
    font-size: 20px;
    font-weight: 600;
    font-family: 'Courier New', Courier, monospace;
    position: relative;
    transition: all 0.3s ease;
    display: inline-block;
    width: 150px;
    box-sizing: border-box;
    overflow: hidden;
    white-space: nowrap;
}

/* Styling for the sequence chunk */
.sequence-text {
    position: relative;
    display: inline-block;
    white-space: nowrap;
    font-weight: 400;
    text-align: center;
    color: #333;
    overflow: hidden;
    text-overflow: ellipsis;
    max-width: 100%;
    pointer-events: none;
    /* user-select: none; */
}

/* Styling for the block number */
.block-number {
    font-size: 12px;
    font-weight: bold;
    background-color: rgba(0, 0, 0, 0.1);
    padding: -2px 5px;
    border-radius: 3px;
    margin-left: 10px;
    user-select: none;
    pointer-events: none;
    position: absolute;
    top: 0; /* Align to the top */
    right: 0; /* Center horizontally */
    transform: translateX(-48%)
}

/* Prevent text overflow issues */
.sequence-text span {
    display: inline-block;
    max-width: 100%;
    text-overflow: ellipsis;
    overflow: hidden;
}

/* Container for the UniProt sequence information */
.uniprot-sequence-info {
    background-color: #f9f9f9;
    padding: 15px;
    border-radius: 8px;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.1);
    font-family: Arial, sans-serif;
    width: 100%;
    max-width: 500px;
    margin: 20px auto;
}

/* Each information row with label and value */
.uniprot-sequence-info .info-row {
    display: flex;
    align-items: center;
    margin-bottom: 10px;
}

/* Label styling */
.uniprot-sequence-info .info-row .label {
    font-weight: bold;
    color: #333;
    flex: 1;
    text-align: left;
}

/* Value styling */
.uniprot-sequence-info .info-row .value {
    font-weight: 500;
    color: #2c3e50;
    padding-left: 8px;
}

/* Separator line */
.uniprot-sequence-info .info-row::before {
    content: '|';
    color: #aaa;
    margin-right: 8px;
    font-size: 18px;
}

/* Styling for each key-value pair to keep space */
.uniprot-sequence-info .info-row:last-child {
    margin-bottom: 0;
}

/* Responsiveness: Stack sequence blocks on smaller screens */
@media screen and (max-width: 768px) {
    #sequenceDisplayer {
        padding: 15px;
    }

    .sequence-block {
        width: 150px;
        margin-bottom: 10px;
    }

    .sequence-text {
        font-size: 16px;
    }

    .block-number {
        font-size: 10px;
    }
}

.details-panel {
    padding: 20px;
    background-color: linear-gradient(135deg, #f4f4f9 0%, #e0e0e0 100%); 
    border: 1px solid #ddd;
    border-radius: 10px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    margin-bottom: 40px;
    /* max-width: 90%; */
    margin: 0 auto;
    overflow: hidden;
    position: relative;
    font-family: 'Arial', sans-serif;
}

.details-panel h2 {
    font-size: 20px;
    color: #007bff;
    font-weight: 600;
    margin-bottom: 15px;
}

.details-panel .localized-sequence {
    font-family: 'Courier New', Courier, monospace;
    max-width: 450px;
    margin: 0 auto;
    font-size: 24px;
    line-height: 1.8;
    color: #333;
    white-space: pre-wrap;
    word-wrap: break-word;
    background-color: #f4f7fa;
    border-radius: 8px;
    padding: 15px;
    border: 1px solid #e0e0e0;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.1);
}

/* Styling for bold PTMs */
.details-panel .localized-sequence strong {
    font-weight: 700;
    color: #e64a19;
}

/* Highlighting the clicked residue */
.details-panel .localized-sequence span.clicked-residue {
    font-size: 20px;
    color: #fff;
    background-color: #007bff;
    border-radius: 50%;
    padding: 5px 8px;
    box-shadow: 0 4px 10px rgba(0, 0, 0, 0.1);
}

/* Add some space between the localized sequence and PTM info */
.details-panel .ptm-info {
    margin-top: 20px;
    font-size: 14px;
    color: #555;
}

/* Panel focus state */
.details-panel:focus {
    outline: 3px solid #007bff;
}

/* Smooth transitions for hover and focus effects */
.details-panel .localized-sequence span:hover {
    background-color: #f5f5f5;
    transition: background-color 0.3s ease;
}

/* Modify the styling for the PTM details container to prevent overflow */
.details-panel .additional-ptm-details {
    margin-top: 20px;
    padding: 15px;
    background-color: #f9f9f9;
    border-radius: 8px;
    border: 1px solid #ddd;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.1);
    word-wrap: break-word;
    white-space: normal;
}

/* Modify the PTM entry to manage link overflow */
.details-panel .ptm-entry {
    padding: 15px;
    margin-bottom: 15px;
    background-color: #f4f7fa;
    border: 1px solid #e0e0e0;
    border-radius: 8px;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.1);
    overflow-wrap: break-word;
    word-wrap: break-word;
}

/* Style for PTM Type label and content */
.details-panel .ptm-entry p strong {
    font-weight: bold;
    color: #007bff;
}

/* Ensure links are nicely separated and can wrap into the next line */
.details-panel .ptm-entry p {
    margin: 5px 0;
    color: #333;
    font-size: 14px;
    word-wrap: break-word;
}

/* Style for evidence identifiers (links) */
.details-panel .ptm-entry p a {
    color: #007bff;
    text-decoration: none;
    display: inline-block;
    margin-right: 10px;
    max-width: 100%;
    word-wrap: break-word;
    overflow-wrap: break-word;
}

/* Hover effect for evidence links */
.details-panel .ptm-entry p a:hover {
    text-decoration: underline;
    color: #0056b3;
}

/* Optional: Add a hover effect for the PTM entries */
.details-panel .ptm-entry:hover {
    background-color: #f1f1f1;
    cursor: default;
}

.details-panel .ptm-scores {
    background-color: #b4b4b4;
    
    border-radius: 4px;
    border: #2c3e50;
    cursor: default;
    max-width: 500px;
    margin: 0 auto;
}

#chunkDetails {
    font-size: 14px;
    line-height: 1.5;
    white-space: pre-wrap;
}

.highlightable-text {
    cursor: default; 
    font-size: inherit;
    user-select: none;
    display: inline-block;
    position: relative;
}

/* General highlighted class for styling */
.highlighted {
    background-color: #f1c40f;
    font-weight: 1000;
    color: #2c3e50;
    border-radius: 4px;
    cursor: pointer;
    transition: transform 0.2s ease, box-shadow 0.2s ease;
    pointer-events: visible;
    line-height: 1;
    margin-bottom: 5px;
}

/* Hover effect on highlighted text */
.highlighted:hover {
    color: #ffffff;
    box-shadow: 0 0 8px rgba(0, 0, 0, 0.3);
}

.custom-tooltip {
    background-color: #333;
    text-align: center;
    color: white;
    padding: 5px;
    font-size: 12px;
    border-radius: 3px;
    position: absolute;
    z-index: 10;
    white-space: nowrap;
    pointer-events: none;
    opacity: 0.8;
}

/* When the tooltip becomes visible */
.custom-tooltip.visible {
    opacity: 1;
    transform: translateY(0);
}

.tooltip:hover {
    display:block;
}

.highlightable-text:hover .tooltip {
    visibility: visible;
    opacity: 1;
}

.tooltip {
    visibility: hidden;
    width: 120px;
    background-color: black;
    color: #fff;
    text-align: center;
    border-radius: 5px;
    padding: 5px;
    position: absolute;
    z-index: 1;
    bottom: 100%;
    left: 50%;
    transform: translateX(-50%);
    opacity: 0;
    transition: opacity 0.3s;
}

.overlay-line {
    position: absolute;
    top: 0;
    left: 50%;
    margin-left: 1px;
    width: 10px;
    height: 100%;
    background-color: #ccc;
    transform: translateX(-50%);
    pointer-events: none;
}


/* THIS IS FOR FILTERING PTM STUFF */

/* Styling for each checkbox list item */
.checkbox-container li {
    display: inline-flex;
    align-items: center;
    margin-right: 10px;
    font-size: 14px;
    padding: 0;
    position: relative;
    user-select: none;
}

/* Hide the checkbox input but keep it functional */
.checkbox-container input[type="checkbox"] {
    width: 0;
    height: 0;
    margin: 0;
    opacity: 0;
    position: absolute;
    pointer-events: none;
}

/* Styling for the labels associated with checkboxes */
.checkbox-container input[type="checkbox"] + label {
    display: inline-flex;
    align-items: center;
    cursor: pointer;
    color: #333;
    background-color: #fff;
    padding: 0 10px;
    font-size: 14px;
    border-radius: 5px;
    transition: background-color 0.3s ease, border-color 0.3s ease;
    box-shadow: 0px 4px 8px rgba(0, 0, 0, 0.05);
    min-height: 16px;
}

/* Hover and checked states for the labels */
.checkbox-container input[type="checkbox"]:not(:checked) + label:hover,
.checkbox-container input[type="checkbox"]:checked + label {
    border-color: #007bff;
    background-color: #f1f1f1;
    color: #007bff;
}

/* Hover effect when checked */
.checkbox-container input[type="checkbox"]:checked + label:hover {
    background-color: #0056b3;
    border-color: #0056b3;
}

/* Styling to ensure the label behaves like a clickable checkbox */
.checkbox-container input[type="checkbox"]:checked + label {
    background-color: #007bff;
    color: white;
    border-color: #007bff;
}

/* Styling for collapsible sections (if needed) */
.accordion {
    background-color: #444;
    color: white;
    cursor: pointer;
    padding: 10px;
    width: 100%;
    text-align: center;
    border: none;
    outline: none;
    font-size: 15px;
    display: flex;
    justify-content: space-between;
    margin-bottom: 5px;
}

.panel {
    display: none;
    padding: 0 18px;
    background-color: #f1f1f1;
    margin-bottom: 10px;
}

.plus {
    font-size: 18px;
}

.accordion:hover {
    background-color: #555;
}

/* Styling for the search box */
#searchBox {
    width: 100%;
    max-width: 350px;
    padding: 12px 20px;
    margin: 0;
    border: 2px solid #ccc;
    border-radius: 8px;
    font-size: 16px;
    box-sizing: border-box;
    display: block;
    background-color: #f9f9f9;
    transition: all 0.3s ease;
}

/* Adjust hover for search box */
#searchBox:hover {
    border-color: #007bff;
}

/* Focus state for the search box */
#searchBox:focus {
    border-color: #007bff;
    outline: none;
    background-color: #fff;
}

/* PTM TABLE OVERVIEW STUFF */
.protein-ptm-overview {
    margin: 20px;
    font-family: Arial, sans-serif;
    font-size: 14px;
}

.protein-ptm-overview__table-wrapper {
    width: 100%;
    height: 600px;
    overflow-x: auto;
}

.protein-ptm-overview__table {
    width: 100%;
    border-collapse: collapse;
    text-align: center;
}

.protein-ptm-overview__table th,
.protein-ptm-overview__table td {
    padding: 8px;
    border: 1px solid #ccc;
}

.protein-ptm-overview__table th {
    background-color: #f2f2f2;
    font-weight: bold;
}

.protein-ptm-overview__table td a {
    color: #007bff;
    text-decoration: none;
}

.protein-ptm-overview__table td a:hover {
    text-decoration: underline;
}

/* EFFECTS FOR ADDITIONAL BUTTONS */
/* General Button Styling */
.additional-button {
    padding: 10px 20px;
    margin: 5px;
    font-size: 16px;
    font-weight: 500;
    border-radius: 8px;
    border: 2px solid transparent;
    background-color: #e3f2fd;
    color: black;
    cursor: pointer;
    transition: all 0.3s ease;
    display: inline-block;
    text-align: center;
    box-shadow: 0 4px 6px rgba(0, 0, 0, 0.1);
}

/* Button Hover Effect */
.additional-button:hover {
    background-color: #c2e3fa;
    box-shadow: 0 6px 12px rgba(0, 0, 0, 0.2);
}

/* Button Focus Effect */
.additional-button:focus {
    outline: none;
    box-shadow: 0 0 10px #b8e2ff;
}

/* Button Active Effect (when clicked) */
.additional-button:active {
    
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.15);
}

/*
    DOUBLE STRUCTURE DISPLAY - USE THIS IN CONJUNCTION WITH MDTRAJ
*/

/* Container for the two PDB structures */
#pdbStructures {
    display: flex;
    justify-content: center;
    align-items: center;
    gap: 20px;
    width: 100%;
    max-width: 100%;
}

#afMajor, #rcsbMajor {
    width: 100%;
    height: 100%;
    align-content: center;
    vertical-align: top;
}

/* Set the size of each PDB viewer */
#afPdbStructure, #rcsbPdbStructure {
    vertical-align: top;
    margin: 0 auto;
    border: 2px solid #000000;
    border-radius: 0px;
    width: 500px;
    height: 500px;
    position: relative;
    overflow: hidden;
}

/*
    USE THIS FOR PROPENSITY TABLES
*/

.PropensityTable {
    width: 100%;
    max-width: 1000px;
    margin: 0px auto;
    margin-top: -10px;
    margin-bottom: 20px;
    border-collapse: collapse;
    background-color: #f8f9fa;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    border-radius: 8px;
    font-family: 'Arial', sans-serif;
    table-layout: fixed;
}

.PropensityTable th {
    padding: 12px 15px;
    text-align: center;
    color: #495057;
    font-size: 1.2rem;
    border-bottom: 2px solid #dee2e6;
}

.PropensityTable td {
    padding: 12px 15px;
    border: 1px solid #dee2e6;
}

.PropensityTable-row {
    border-bottom: 1px solid #ddd;
}

.PropensityTable-key {
    background-color: #f1f3f5;
    color: #212529;
    font-weight: 600;
    text-align: left;
    border-right: 1px solid #dee2e6;
    max-width: 200px;
    word-wrap: break-word;
}

.PropensityTable-value {
    background-color: #ffffff;
    color: #495057;
    text-align: center;
    border-right: 1px solid #dee2e6;
    max-width: 250px;
    word-wrap: break-word;
}

.PropensityTable-notes {
    background-color: #ffffff;
    color: #495057;
    text-align: left;
    max-width: 500px;
    word-wrap: break-word;
}

.PropensityTable-row:hover {
    background-color: #f1f3f5;
}

.PropensityTable-notes math {
    font-size: 1rem;
    line-height: 1.6;
}

@media (max-width: 1079px) {
    .PropensityTable {
        width: 100%;
        padding: 0 10px;
    }

    .PropensityTable-key,
    .PropensityTable-value,
    .PropensityTable-notes {
        padding: 10px 8px;
    }

    .PropensityTable th {
        font-size: 1rem;
        padding: 10px 12px;
    }
}

/*
    AND DISPLAYING THE VECTOR ITSELF
*/

#ptmVector {
    margin-left: auto;
    margin-right: auto;
    padding: 40px;
    max-width: 1000px;
    width: 100%;
    display: block;
}

#dataVector {
    width: 100%;
    border-collapse: collapse;
    text-align: center;
    margin-left: auto;
    margin-right: auto;
}

#dataVector th, #dataVector td {
    padding: 2px 4px;
    border: 1px solid #ddd;
    text-align: center;
    vertical-align: middle;
}

#dataVector th {
    background-color: #A0C4FF;
    font-size: 1rem;
    font-weight: 600;
    color: #495057;
}

#dataVector td {
    background-color: #ffffff;
    font-size: 1rem;
    color: #495057;
}

#dataVector td:hover {
    background-color: #f1f3f5;
    cursor: pointer;
}

#dataVector td[style*="background-color: rgb(242, 201, 152)"] {
    background-color: #F2C99A;
    font-weight: bold;
}

#vectorHead {
    background-color: #A0C4FF;
    color: white;
}

@media (max-width: 1079px) {
    #dataVector {
        width: 100%;
        font-size: 0.9rem;
    }

    #dataVector th, #dataVector td {
        padding: 8px 15px;
    }
}

/*
    PAGE-EXCLUSIVE STUFF
*/

#markdown {
    background-color: #f9f9f9;
    border: 1px solid #ddd;
    border-radius: 8px;
    padding: 20px;
    margin: 20px auto;
    max-width: 1280px;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
    font-family: Arial, sans-serif;
    line-height: 1.6;
    width: 70%;
}

#swagger-ui {
    margin: 20px;
    padding: 20px;
    border: 1px solid #ccc;
    background-color: #f4f4f4;
}

/* DOWNLOADS PAGE */

.custom-download {
    background-color: #f8f9fa;
    font-family: Arial, sans-serif;
    padding: 20px;
    border-radius: 10px;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
    max-width: 600px;
    margin: auto;
    padding-bottom: 10px;
}

.custom-download h2 {
    color: #343a40;
    text-align: center;
    margin-bottom: 20px;
}

.custom-download .form-label {
    font-weight: bold;
    margin-bottom: 10px;
    color: #495057;
}

.custom-download .form-select {
    border: 2px solid #007bff;
    border-radius: 5px;
    padding: 10px;
    transition: border-color 0.3s;
}

.custom-download .form-select:focus {
    border-color: #0056b3;
    box-shadow: 0 0 5px rgba(0, 123, 255, 0.5);
}
/* 
.custom-download #downloadButton {
    width: 100%;
    margin-top: 20px;
    background-color: #007bff;
    border: none;
    border-radius: 5px;
    padding: 10px;
    color: white;
    font-weight: bold;
    transition: background-color 0.3s, transform 0.2s;
}

.custom-download #downloadButton:hover {
    background-color: #0056b3;
    transform: translateY(-2px);
} */

/* ABOUT PAGE */

.team-member {
    margin-bottom: 30px;
}

.team-member img {
    border-radius: 50%;
    width: 120px;
    height: 120px;
    object-fit: cover;
    margin-top: 15px;
}

.team-member .card {
    width: 350px;
    height: 280px;
    border: none;
    box-shadow: 0 2px 10px rgba(0, 0, 0, 0.1);
}

.team-member .card-body {
    text-align: center;
}

.team-member h4 {
    font-size: 1.2rem;
    font-weight: bold;
    margin-bottom: 10px;
}

.team-member p {
    font-size: 1rem;
    color: #555;
}

.team-member a {
    font-size: 1rem;
    color: #007bff;
    text-decoration: none;
}

.team-member a:hover {
    text-decoration: underline;
}

.team-container {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(300px, 1fr));
    gap: 20px;
    padding: 20px;
}

.publication-list {
    list-style-type: none;
    padding: 0;
}

.publication-item {
    background-color: #ffffff;
    padding: 15px;
    margin: 10px 0;
    border-radius: 8px;
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
}

.publication-item p {
    margin: 5px 0;
    color: #555;
}

.publication-item strong {
    color: #333;
}

.publication-item .special-issue {
    color: #2d6a4f;
    font-style: italic;
}

.pub-number {
    font-weight: bold;
    font-size: 1.2rem;
}

.question-mark {
    color:#fff;
    background-color:#0077ff;
    width:16px;
    height:16px;
    display:inline-block;
    border-radius:100%;
    font-size:10px;
    text-align:center;
    text-decoration:none;
    -webkit-box-shadow: inset -1px -1px 1px 0px rgba(0,0,0,0.25);
    -moz-box-shadow: inset -1px -1px 1px 0px rgba(0,0,0,0.25);
    box-shadow: inset -1px -1px 1px 0px rgba(0,0,0,0.25);
}

/* FOR CONTENTEDITABLE INPUT */

[contenteditable=true]:empty:before {
    content: attr(placeholder);
    pointer-events: none;
    color: #999;
    display: block;
}