Welcome to
PERCEPTRON-PTMKB V2
PERCEPTRON-PTMKB is designed to serve data on post translational modifications (PTMs) of proteins.
Examples:P04637 (TP53)G6PI_HUMAN (entry name)VP26A_MOUSE (entry name)O14639-4 (isoform)P25311 (AZGP1)P00533 (EGFR)P38398 (BRCA1)
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Recently Added
What's New in V2
Enzyme–Substrate Data
Evidence-backed interactions between enzymes and the specific residues they modify, linking each PTM site to its likely writer enzyme.
View example protein →Spatial Propensity
An updated scoring model that factors in 3D structural context alongside sequence, reflecting each site's real spatial environment, not just its sequence neighborhood.
Try the calculator →Graded & Literature-Linked Evidence
Every site carries a confidence tier — Experimentally-Verified, Consensus-Predicted, UniProt-Predicted, or Validation-Pending — backed by standardized Evidence and Conclusion Ontology (ECO) codes and linked directly to the PubMed records that support it, so you can judge trustworthiness and trace it to its source at a glance.
View example site →Expanded API Integration
A broader set of REST endpoints covering proteins, enzymes, and PTMs, built for deeper integration into your own research pipelines.
Explore endpoints →PTM-Enabled Molecular Dynamics
Simulated dynamics of proteins bearing specific modifications, to explore how a PTM reshapes structure and behavior over time.
Coming soonDynamically Updating Database
Continuously refreshed against UniProt and source databases, so entries stay current as accessions are merged, renamed, or retired.
Find a protein to look up →PTMKB Workflow
Using REST API
A simple, efficient, and easy-to-integrate script for your workflow.
Download Script